WG 1: Symmetry Breaking

Symmetry Breaking

Todd McDevitt

Calin Belta

Melissa Kemp

Michael Levin

Hang Lu

Steven Stice

Objective: Direct the co-differentiation of pluripotent stem cells to achieve controlled spatial patterning of multicellular constructs by harnessing biochemical, bioelectrical, and biophysical cues with a focus on initial symmetry breaking.

 

Hypothesis: Coincident differentiation of divergent cell phenotypes with appropriate spatial control is required to achieve functional organoids.